According to two recently published randomized, double-blind, placebo-controlled studies, CLA significantly increases lean body mass and produces modest reductions in body fat loss in humans.

Previous research in animals has also found that CLA appears to help improve glucose tolerance and leads to reductions in body weight independent of food intake.

CLA or conjugated linoleic acid refers to a group of linoleic acid (Omega-6) isomers naturally found in eggs, dairy products (particularly full-fat dairy products), animal tissues, and specially prepared safflower and sunflower oils. While the mechanisms behind how CLA encourages loss of body fat with subsequent gains in lean muscle aren't well understood, CLA may inhibit lipoprotein lipase. Lipoprotein lipase is an enzyme that breaks down dietary fats, enabling them to be stored as body fat.

Daily supplementation with 3 to 6 grams of CLA, in divided doses, is consistent with the amounts used in most human trials.

Sources: American Journal of Clinical Nutrition & Journal of Nutrition. May 2007
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