Creatine Supplementing Synthesis

Creatine is perhaps the most well publicized, well studied, most widely used, and most effective sports supplement on the market today. Despite this, some individuals still express a concern that supplementing with creatine may cause the body to produce less creatine on its own during use, or potentially even stop its own natural production completely.

A recent study conducted at Peking University may have put this line of thinking to rest once and for all. Researchers gave lab rats very large doses of supplemental creatine every day for a week and noticed that the initial suppression of creatine synthesis began subsiding after just 4 days. Between days 8 and 12, not only did the suppression effect cease, but levels actually began to exceed normal synthesis.

The Bigger Picture: Athletes typically load with creatine using 5 grams 4-5 times per day for a week followed by 5 grams per day for an additional 6 to 8 weeks. Although we don't recommend taking the kind of doses used in the Peking University study, using creatine as directed can help you attain new levels of strength, endurance, and performance benefits in a relatively short amount of time.
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Jun 27, 2008
This is true. I have both seen and felt this happening to me. No iam not a rat.....well a gym-rat yes but no lab-rat.
Now i use extra caution when supplementing creatine.
O.N. " The Bigger, Better, Stronger Picture"
Jun 27, 2008
What are your thoughts on Creatine Ethyl Ester vs Creatine?
Jul 17, 2008
with Creatine Ethyl Ester i felt the effects were at least 5 times stronger vs creatine